Zinc is a very important mineral in the body. It is involved in over 200 different enzyme systems.  It is because of zinc's crucial importance in collagen synthesis and repair that it is included in LigaGenix.

Zinc's involvement in collagen synthesis appears to be through two different enzymes, procollagen N-proteinase, and procollagen C-proteinase. These two enzymes are required for processing the soluble precursor (procollagen) to collagen.(1) Zinc deficiency in test animals resulted in a 30% lower total muscle collagen synthetic activity, as compared to non-deficient.(2) In another animal study, zinc deficiency was shown to result in markedly altered bone metabolism, with a significant reduction in collagen synthesis and turnover. Bone collagenase activity was reduced by 40%-80%.(3) In yet a third study on zinc's impact on wound healing, it was found that there was a significant delay in the healing of excised wounds in zinc-deficient animals, and that the development of tensile strength in incised wounds was also significantly less when measured at the same time as control animals. (4)


  1. D.J. Prockop, A.L. Sieron and S. W. Li. Procollagen N-proteinase and procollagen C-protienase. Two unusual metalloproteinases that are essential for procollagen processing probably have important roles in developement and cell signaling. Matrix Biology 16;399-408 (1998).
  2. McClain, P., Wiley, E. et al.  Influence of zinc deficiency on synthesis and cross-linking of rat skin collagen Biochemica et Biophysica Acta Volume 304, Issue 2, 28 April 1973, pp 457-465
  3. Starcher, B., Hill, C. and Madras, J. Effect of Zinc Deficiency on Bone Collagenase and Collagen Turnover. American Society for Nutrition, April 1980
  4. Rahmat, A., Norman, J., and Smith, G. The Effect of Zinc Deficiency on Wound Healing.  British Journal of Surgery, Volume 61, Issue 4, pp. 271-273 April 1974