Silicon

Silicon is one of the top ten elements in the body and a very important and often overlooked element for construction and healing of connective tissue. There are, in fact, 7 grams of silicon in the body, almost twice the amount of iron. Observational and interventional trials have shown favorable correlations between silicon consumption and the health of bone and connection tissue. Supplemental silicon’s effectiveness in increasing collagen production was demonstrated in a Belgian study that showed an increase in skin collagen content in calves supplemented with silicon. While high levels of silicon in the fetus, this declines dramatically with age, with as much as an 80% decline in the elderly. It is estimated that as much as 15-25 mg of elemental silicon is needed daily for connective tissue maintenance, with up to 40 mg for collagen restructuring, however no formal RDA exists for this element.

Silicon’s effectiveness in increasing collagen production appears to be due to the fact that it is a constituent of the enzyme prolyl hydrolase, which helps the body produce both collagen and gycosaminoglycans, important for connective tissue and joint health. In one study, silicon supplementation increased collagen type I synthesis in cells treated with supplemental silicon. Conversely, the synthesis of collagen decreases in the case of silicon deficiency with studies showing that silicon deprivation decreases collagen formation in wounds and bone. In addition to facilitating collagen production, supplemental silicon has interestingly enough been found to decrease the pain of tendonitis. Finally, silicon and boron combined together have a synergistic effect, that is why you will find both of these essential elements included in LigaGenix.

References:

  1. Si-G5 (Organic Silicon-G5) http://www.le-silicium-organique.com/doc/Documents/SiliciumOrganiqueG5%20EN.pdf
  2. Martin KR. The chemistry of silica and its potential health benefits. J Nutr Health Aging. 2007 Mar-Apr;11(2):94-7.
  3. Calomme MR, Vanden Berghe DA. Supplementation of calves with stabilized orthosilicic acid. Effect on the Si, Ca, Mg, and P concentrations in serum and the collagen concentration in skin and cartilage. Biol Trace Elem Res. 1997 Feb;56(2):153-65.
  4. Reffitt DM, Ogston, N., Jugdaohsingh, R.et al. Orthosilicic acid stimulates collagen type 1 synthesis and osteoblastic differentiation in human osteoblast-like cells in vitro. Bone. 2003 Feb;32(2):127-35.
  5. Calcif Tissue Int 2002;70:292, P-139
  6. Jugdaohsingh R, et al. Dietary silicon intake is positively associated with bone mineral density in men and premenopausal women of the Framingham Offspring cohort. Bone 2003 May;32,:S192
  7. Seaborn, C.D. and Nielsen, F.H. Silicon deprivation decreases collagen formation in wounds and bones, and ornithine transaminase enzyme activity in liver. Biological Trace Element Research. Volume 89(3) 251-261.
  8. Wickett RR, Effect of oral intake of choline-stabilized orthosilicic acid on hair tensile strength and morphology in women with fine hair. Arch Dermatol Res. 2007 Dec;299(10):499-505.
  9. Silicon: http://nhiondemand.com {accessed 18 Dec 2008)